Northeast Missouri Vacation Packages 2026 from $340

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Your Northeast Missouri Vacation

When you're ready for your next big adventure, our Northeast Missouri vacation packages are the answer. Dining and culture are among the many things that make this destination truly unforgettable. Kick off your trip to Northeast Missouri with some time exploring St. Louis visiting popular sights like Enterprise Center and Busch Stadium. St. Charles is another top city that draws travelers from far and wide. Ameristar Casino St. Charles and Westport Plaza are two of the leading places to see in this destination. From the moment you book your Northeast Missouri vacation to when you get back home, Expedia will take care of you each step of the way.

The Latest Northeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

Save 100% on your flight

$340

per person

Sep 27 - Oct 2

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,676 reviews)

This was a very nice property and had a great area for our dogs. The front desk lady was very nice and there were treats for our dogs. We will definitely stay here again when in the St. Louis area. The room was clean and decorated nicely. Two thumbs up!!

Reviewed on Aug 20, 2026

The Cheshire

Save 100% on your flight

$400

per person

Sep 24 - Sep 28

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,006 reviews)

Remodeled and Inviting Free EV

Save 100% on your flight

$535

per person

Sep 27 - Oct 2

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

10/10 Exceptional! (1 review)

It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it

Reviewed on Aug 7, 2026

Crowne Plaza St. Louis Airport by IHG

Save 100% on your flight

$344

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8/10 Very Good! (1,005 reviews)

Alhonna Resort LLC

Save 100% on your flight

$1,015

per person

Sep 26 - Oct 3

found 1 day ago

Roundtrip flight included

Denver (DEN) to St. Louis (STL)

8.8/10 Excellent! (328 reviews)

Location was wonderful Pool was refreshing We had an enjoyable overnight stay

Reviewed on Aug 17, 2026

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Where to stay in Northeast Missouri

Find the best Northeast Missouri areas and neighborhoods for the activities you enjoy most. Learn more about Northeast Missouri

The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

An ornate hall with arched ceilings and intricate patterns.

Downtown West

3 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Stay near popular Northeast Missouri attractions

A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.

Busch Stadium

9.4/10 (4,850 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.

See properties

A bronze elephant sculpture with a pumpkin on its back, surrounded by greenery.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

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A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)

Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.

See properties

A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)

Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's great live music and fascinating museums.

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A modern building with large glass windows, surrounded by a garden with red and pink tulips and purple flowers.

Forest Park

9.2/10 (3,389 reviews)

Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.

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A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)

This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.

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A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)

Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.

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America's Center Convention Complex

8.8/10 (306 reviews)

Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.

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What to do in Northeast Missouri

Kansas City MO Attractions Pass

$30

per adult

Kansas City: Kansas City Tap Tour

per adult

Tom's Town Distillery Tour and Tasting

$27

per adult

100% of travellers recommend

See all activities in Northeast Missouri

Northeast Missouri Hotel Deals

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

$92 nightly

$107 total

Sep 6 - Sep 7

Total with taxes and fees

9/10 Wonderful! (3,357 reviews)

"Nice up to date room. I especially liked the reading lights attached to the bed. Very convenient location. Nice selections for breakfast. We were surprised by the city's overnight road resurfacing, but it didn't keep us awake."

Reviewed on Aug 20, 2026

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Fully refundableReserve now, pay when you stay

$125 nightly

$146 total

Sep 2 - Sep 3

Total with taxes and fees

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$118 nightly

$138 total

Sep 6 - Sep 7

Total with taxes and fees

8.4/10 Very Good! (1,155 reviews)

"This is a motel and it was not a safe place so I didn’t check in and left."

Reviewed on Aug 20, 2026

See all 3,008 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.