Northeast Missouri Vacations from $209

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Your Northeast Missouri Vacation

When you're ready for your next big adventure, our Northeast Missouri vacation packages are the answer. Dining and culture are among the many things that make this destination truly unforgettable. Kick off your trip to Northeast Missouri with some time exploring St. Louis visiting popular sights like Enterprise Center and Busch Stadium. St. Charles is another top city that draws travelers from far and wide. Ameristar Casino St. Charles and Westport Plaza are two of the leading places to see in this destination. From the moment you book your Northeast Missouri vacation to when you get back home, Expedia will take care of you each step of the way.

The Latest Northeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Riverport
Save 100% on your flight
$209
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.8/10 Good! (1,005 reviews)
Stains on the carpet floor. They initially alloted a room that was not cleaned, later we were shifted to a cleaned room when we told the issue. No phone lines between rooms were working. Utensils were old and lots of scrteches on pans. For few days only one elevator was working. Some of the guests at the property were lound on the parking and there was also incident where cops were called to interfere.

Reviewed on Oct 7, 2026

The Wildwood Hotel

The Wildwood Hotel

$279
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,679 reviews)
The Knight Center at Washington University

The Knight Center at Washington University

Save 100% on your flight
$345
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (690 reviews)
All great except the very noisy toilet. When you flesh, you probably can wake up whole saint louis

Reviewed on Oct 7, 2026

Moonrise Hotel

Moonrise Hotel

Delmar Loop
Save 100% on your flight
$351
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (2,029 reviews)
I was really looking forward to stayng at this property however, my room had quite a few broken items and was simply not very clean. The bed had one side that was sunken and very uncomfortable. When I got into my room after just having driven 10 hours the TV did not work for the 1st 24 hours. I just wanted to relax and watch the news, not to mention I couled not watch college football the following day. The hotel's in room phones were not working the entire time so I would have to call the front desk with my personal phone of which was not a problem but when calling I would not get the front desk and instead was re-routed to several other departments and then I was told they were busy and to call back. I was never able to reach them and had to go down to the front desk few times; each time I would go down there was no other customers in line and were not busy at all even though this is what I was told by the multiple people I was re-routed to. The room itself was not at all what I expected or described on Expedia as well as their own website. The room was not very clean and I ended up using my lysol sheets to wipe everything down.

Reviewed on Oct 7, 2026

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Save 100% on your flight
$427
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,062 reviews)
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Where to stay in Northeast Missouri

Find the best Northeast Missouri areas and neighborhoods for the activities you enjoy most. Learn more about Northeast Missouri
The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

An ornate hall with arched ceilings and intricate patterns.

Downtown West

2 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
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A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
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A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.
Photo by Carl Guttovz

Busch Stadium

9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
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A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
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A stone fountain with water cascading down a tiered structure, surrounded by a pond and a grassy area with a building in the background.

Forest Park

9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
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A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.
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A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
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America's Center Convention Complex

8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.
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What to do in Northeast Missouri

 Kansas City MO Attractions Pass

Kansas City MO Attractions Pass

$30
per adult
Kansas City MO Attractions Pass
Tom's Town Distillery Tour and Tasting

Tom's Town Distillery Tour and Tasting

$27
per adult
100% of travellers recommend
Tom's Town Distillery Tour and Tasting
Kansas City: Country Club Plaza Escape Game

Kansas City: Country Club Plaza Escape Game

$43
per adult
Kansas City: Country Club Plaza Escape Game
See all activities in Northeast Missouri

Northeast Missouri Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$92 nightly
$107 total
Oct 25 - Oct 26
Total with taxes and fees
Clayton Plaza Hotel & Extended Stay
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
$89 nightly
$106 total
Oct 15 - Oct 16
Total with taxes and fees
Pear Tree Inn St. Louis Airport
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$108 nightly
$127 total
Nov 1 - Nov 2
Total with taxes and fees
Hollywood Casino & Hotel St. Louis
See all 3,010 properties in Northeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Northeast Missouri Vacation Packages

Northeast Missouri Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

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