Title: Northeast Missouri Vacation Packages 2026 from $235 | Expedia.com [Northeast Missouri Travel Guide](https://expedia.com/Northeast-Missouri.dx6058818)[Hotels in Northeast Missouri](https://expedia.com/Northeast-Missouri-Hotels.d6058818.Travel-Guide-Hotels)[Vacation Rentals in Northeast Missouri](https://expedia.com/Northeast-Missouri-Vacation-Rentals.d6058818.Travel-Guide-VacationRentals)[Flights to Northeast Missouri](https://expedia.com/Cheap-Flights-To-Northeast-Missouri.d6058818.Travel-Guide-Flights)[Things to do in Northeast Missouri](https://expedia.com/Things-To-Do-In-Northeast-Missouri.d6058818.Travel-Guide-Activities)[Car Rentals in Northeast Missouri](https://expedia.com/Car-Rentals-In-Northeast-Missouri.d6058818.Car-Rental-Guide) ![](https://images.trvl-media.com/place/10540/802bf5d7-a3f6-4e16-b933-40ae5b4ec325.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Northeast Missouri Vacations from $235 ## Book a Hotel + Flight or Car together to unlock savings Photo by Andrew Hershfeld - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Northeast Missouri Vacation When you're ready for your next big adventure, our Northeast Missouri vacation packages are the answer. Dining and culture are among the many things that make this destination truly unforgettable. Kick off your trip to Northeast Missouri with some time exploring [St. Louis](https://www.expedia.com/St-Louis.d178309.Destination-Travel-Guides) visiting popular sights like Enterprise Center and Busch Stadium. [St. Charles](https://www.expedia.com/St-Charles.d9786.Destination-Travel-Guides) is another top city that draws travelers from far and wide. Ameristar Casino St. Charles and Westport Plaza are two of the leading places to see in this destination. From the moment you book your Northeast Missouri vacation to when you get back home, Expedia will take care of you each step of the way. ## The Latest Northeast Missouri vacation packages Price found within the past 48 hours. Click for updated prices. ![HoteLumiere at the Arch - A Caesars Rewards Destination](https://images.trvl-media.com/lodging/2000000/1830000/1828900/1828851/96d30602_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### HoteLumiere at the Arch - A Caesars Rewards Destination Downtown St. Louis $235 per person Jun 24 - Jun 26 found 1 day ago Roundtrip flight included Dallas (DFW) to St. Louis (STL) 6.8/10 (1,000 reviews) Definitely needs some updates and a little TLC Reviewed on Mar 9, 2026 ![Crowne Plaza St. Louis Airport by IHG](https://images.trvl-media.com/lodging/1000000/10000/3100/3010/90ecdcdc_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Crowne Plaza St. Louis Airport by IHG $371 per person May 6 - May 10 found 1 day ago Roundtrip flight included Dallas (DFW) to St. Louis (STL) 8/10 Very Good! (1,007 reviews) The staff was very attentive and friendly. The pool was empty, so that was disappointing. We did enjoy our balcony room. Reviewed on Apr 2, 2026 ![Home2 Suites by Hilton St. Louis Downtown](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510729/104b5741_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Home2 Suites by Hilton St. Louis Downtown Downtown West $289 per person Jun 24 - Jun 26 found 1 day ago Roundtrip flight included Dallas (DFW) to St. Louis (STL) 8/10 Very Good! (696 reviews) Breakfast was decent expected a better variety of food.Room was nice Reviewed on Mar 31, 2026 ![Spacious 3-Bedroom with King Bed](https://images.trvl-media.com/lodging/110000000/109680000/109680000/109679988/f2203ae1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Spacious 3-Bedroom with King Bed Central West End Save 100% on your flight $566 per person Jun 24 - Jun 26 found 1 day ago Roundtrip flight included Dallas (DFW) to St. Louis (STL) 8.8/10 Excellent! (11 reviews) Clean room nice area Reviewed on Feb 1, 2026 ![Hilton Garden Inn St. Louis/O'Fallon MO](https://images.trvl-media.com/lodging/1000000/930000/921500/921433/e9a336ca_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hilton Garden Inn St. Louis/O'Fallon MO $711 per person May 13 - May 16 found 21 hours ago Roundtrip flight included New York (NYC) to St. Louis (STL) 8.8/10 Excellent! (731 reviews) Did not eat there breakfast use gym but all was good especially the staff Reviewed on Mar 28, 2026 Don't see what you're looking for? See all available trips from Columbus to Northeast Missouri [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-05-03/2026-05-10/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=STL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Where to stay in Northeast Missouri Find the best Northeast Missouri areas and neighborhoods for the activities you enjoy most. [Learn more about Northeast Missouri](https://expedia.com/Northeast-Missouri.dx6058818) ![St. Louis Missouri](https://images.trvl-media.com/place/6058846/ad61b28c-fc90-4997-9e8c-7d09999a125f.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Clayton 1 out of top 10 points of interest in this area Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station. [Find hotel + flight trips in Clayton](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Clayton&DestID=6058846&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Downtown West](https://images.trvl-media.com/place/3284/7d953ffd-a093-422e-8101-35af3b9eb6fc.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown West 3 out of top 10 points of interest in this area If you're spending some time in Downtown West, St. Louis Union Station and Enterprise Center are top sights worth seeing. [Find hotel + flight trips in Downtown West](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Downtown%20West&DestID=553248635976473134&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![St. Louis](https://images.trvl-media.com/place/6272/26979a45-e5a8-4066-9ddd-1ba301b4bd4a.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Berkeley Visitors highly recommend Berkeley for its abundant dining options, and you can make a stop by James S. McDonnell Prologue Room while you're in town. [Find hotel + flight trips in Berkeley](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Berkeley&DestID=6272&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Central West End](https://images.trvl-media.com/place/6175135/a1a4060c-5623-4543-941c-91e3f85f02cc.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Central West End 4.5/5(456 area reviews) Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis. [Find hotel + flight trips in Central West End](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Central%20West%20End&DestID=6175135&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Creve Coeur Lake, Saint Louis, Missouri Fall Season](https://images.trvl-media.com/place/7717/99c4d9ff-92a3-4e6a-85fa-a8b0fe6fb3f3.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Creve Coeur Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town. [Find hotel + flight trips in Creve Coeur](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Creve%20Coeur&DestID=7717&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ### Discover the most popular places to visit in Northeast Missouri ![Union Station, St. Louis, MO](https://images.trvl-media.com/place/502868/8704491b-9324-4c56-89ed-94a638702313.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### St. Louis Union Station You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game. [](https://expedia.com/St-Louis-Union-Station-Downtown-West.d502868.Vacation-Attraction) ![Busch Stadium](https://images.trvl-media.com/place/3284/67189e41-0060-455b-85a9-ab65c9125a63.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Busch Stadium Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a baseball game. [](https://expedia.com/Busch-Stadium-Downtown-St-Louis.d502872.Vacation-Attraction) ![St. Louis Zoo](https://images.trvl-media.com/place/502878/51adfd0a-5175-4aa9-aa40-2221835ea3ae.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### St. Louis Zoo In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world. [](https://expedia.com/St-Louis-Zoo-St-Louis.d502878.Vacation-Attraction) ### What to do in Northeast Missouri ![Kansas City: Kansas City Tap Tour](https://mediaim.expedia.com/localexpert/48196637/8368eb46-dcaf-414e-968d-ef44f60b8150.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Kansas City: Kansas City Tap Tour $5 per adult [](https://expedia.com/things-to-do/kansas-city-kansas-city-tap-tour.a48196637.activity-details) ![ Kansas City MO Attractions Pass](https://mediaim.expedia.com/localexpert/48553911/86e435fe-da53-4a05-bb78-ef13a2da2e49.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Kansas City MO Attractions Pass $30 per adult [](https://expedia.com/things-to-do/kansas-city-mo-attractions-pass.a48553911.activity-details) ![Tom's Town Distillery Tour and Tasting](https://mediaim.expedia.com/localexpert/1000934/77cc3165-9ea9-47f8-8d0c-8dc6d1e77a52.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Tom's Town Distillery Tour and Tasting $27 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/toms-town-distillery-tour-and-tasting.a1000934.activity-details) [See all activities in Northeast Missouri](https://expedia.com/things-to-do/search?rid=6058818) ## Northeast Missouri Hotel Deals ![Pear Tree Inn St. Louis Near Union Station](https://images.trvl-media.com/lodging/1000000/30000/26600/26572/3056142b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Pear Tree Inn St. Louis Near Union Station 2211 Market Street St. Louis MO Fully refundableReserve now, pay when you stay $113 nightly $132 total Apr 13 - Apr 14 Total with taxes and fees 8.8/10 Excellent! (1,915 reviews) Food was good Reviewed on Apr 3, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F13%2F2026&endDate=4%2F14%2F2026&selected=26572&PinnedHotelID=26572&HadPinnedHotel=true®ionId=6058818) ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/bd7064dc_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 21C Museum Hotel St Louis 1528 Locust street St. Louis MO Fully refundableReserve now, pay when you stay $148 nightly $173 total May 3 - May 4 Total with taxes and fees 9/10 Wonderful! (1,716 reviews) Second time I've stayed, and the last! First time room was super dirty, same goes the second. Gross orange mold in the comers of the shower. Waited 2 hours past our 4:00 check-in for our rooms, not a 'sorry' or any kind of comp. Valet tried to charge me for a two day stay as well. Took three days ... Reviewed on Apr 2, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F3%2F2026&endDate=5%2F4%2F2026&selected=89164592&PinnedHotelID=89164592&HadPinnedHotel=true®ionId=6058818) ![Clayton Plaza Hotel & Extended Stay](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/5c61cbf8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Clayton Plaza Hotel & Extended Stay 7750 Carondelet Avenue St. Louis MO Fully refundableReserve now, pay when you stay $94 nightly $110 total Apr 19 - Apr 20 Total with taxes and fees 8.8/10 Excellent! (3,125 reviews) Parking was not close. Room was not great with shabby curtains and walls. Bathroom was nice. Breakfast was good. Staff was nice. Reviewed on Apr 3, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F19%2F2026&endDate=4%2F20%2F2026&selected=18144&PinnedHotelID=18144&HadPinnedHotel=true®ionId=6058818) [See all 2,915 properties in Northeast Missouri](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=4%2F4%2F2026&endDate=4%2F5%2F2026®ionId=6058818) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Northeast Missouri Vacation Packages ## Northeast Missouri Essential Information | Language | English | | --------------- | ------------------------------------- | | Currency | U.S dollars | | Closest Airport | Lambert-St. Louis Intl. Airport (STL) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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